Magnetic Resonance Imaging
نویسندگان
چکیده
Background—Because of rapid changes in myocardial intracellular Na (Na i) during ischemia and reperfusion (R), Na magnetic resonance imaging (MRI) appears to be an ideal diagnostic modality for early detection of myocardial ischemia and viability. So far, cardiac Na MRI data are limited and mostly concerned with imaging of total Na . For proper interpretation, imaging of both Na i and extracellular Na is essential. In this study, we tested whether Na i imaging can be used to assess viability after low-flow (LF) ischemia. Methods and Results—Isolated rat hearts were subjected to LF (1%, 2%, or 3% of control coronary flow) and R. A shift reagent was used to separate Na i and extracellular Na resonances. Acquisition-weighted Na chemical shift imaging (CSI) was alternated with Na MR spectroscopy. Already during control perfusion, Na i could be clearly seen on the images. Na i image intensity increased with increasing severity of ischemia. During R, Na i image intensity remained highest in 1% LF hearts. Not only did we find very good correlations between Na i image intensity at end-R and end-diastolic pressure (R 0.85, P 0.001) and recovery of the rate-pressure product (R 0.88, P 0.001) at end-R, but most interestingly, also Na i image intensity at end-LF was well correlated with end-diastolic pressure (R 0.78, P 0.01) and with recovery of the rate-pressure product (R 0.81, P 0.01) at end-R. Furthermore, Na i image intensity at end-LF was well correlated with creatine kinase release during R (R 0.79, P 0.05) as well as with infarct size (R 0.77, P 0.05). Conclusions—These data indicate that Na CSI is a promising tool for the assessment of myocardial viability. (Circulation. 2004;110:3457-3464.)
منابع مشابه
Use of Magnetic Resonance Imaging in Food Quality Control: A Review
Modern challenges of food science require a new understanding of the determinants of food quality and safety. Application of advanced imaging modalities such as magnetic resonance imaging (MRI) has seen impressive successes and fast growth over the past decade. Since MRI does not have any harmful ionizing radiation, it can be considered as a magnificent tool for the quality control of food prod...
متن کاملStatic Coil Design Considerations for the Magnetic Resonance Imaging
One of the main challenges in developing magnetic resonance imaging (MRI) systems is to create a static coil that needs to generate magnetic field density along with the characteristics of optimal homogeneity and magnitude size. To do this, two N42 Block PMs are used and the iron core is designed and optimized in accordance with the dimensions of PM pieces using ANSYS Maxwell software. Then, al...
متن کاملANALYTICAL STUDY OF EFFECT OF BILAYER INORGANIC AND ORGANIC COATING AROUND THE IRON OXIDE NANOPARTICLES ON MAGNETIC RESONANCE IMAGING CONTRAST
Background & Aims: In recent years, iron oxide nanoparticles have been used in contrast-enhanced magnetic resonance imaging for diagnosing a wide range of diseases. In order to provide biocompatibility and prevent the toxicity of the nanoparticles, using organic or inorganic coating around these nanoparticles is important for their application. The aim of this study is to investigate the effect...
متن کاملApplication of Magnetic Resonance Imaging (MRI) as a safe & Application of Magnetic Resonance Imaging (MRI) as a safe & non-destructive method for monitoring of fruit & vegetable in postharvest period
To investigate and control quality, one must be able to measure quality-related attributes. Quality of produce encompasses sensory attributes, nutritive values, chemical constituents, mechanical properties, functional properties and defects. MRI has great potential for evaluating the quality of fruits and vegetables. The equipment now available is not feasible for routine quality testing. The ...
متن کاملA New Potential Contrast Agent for Magnetic Resonance Imaging: Iron Oxide-4A Nanocomposite
Background: Magnetic resonance imaging (MRI) contrast agents have an important role to differentiate healthy and diseased tissues. Access and design new contrast agents for the optimal use of MRI are necessary. This study aims to evaluate iron oxide–4A nanocomposite ability to act as a magnetic resonance imaging contrast agent.Materials and Methods: Iron oxide–4A nanocomposite (F4A) was syn...
متن کامل